Note:
The value d in record status (Rec Stat) in a record (Leader Byte 05 (Leader/05)) indicates that institution-level holdings should be canceled on that record.
If your local system can output a file with record status d for those records on which you want to cancel holdings, you can send a single MARC file, and batch processing can use the record status value to set holdings for matching records with any value except d and cancel holdings on matching records with value d.
If your local system cannot output records with a Record Status d, you can order separate collections for two separate sets of records. Here are two options: